Member of Technical Staff, Infrastructure and Training Systems
Radical Numerics · San Francisco
About Us
Radical Numerics is an AI research lab building general biological intelligence. Our mission is to master the code of life, and our purpose is to reduce human suffering.
Our team created Evo, and started the field of generative genomics. Our work was featured on the cover of Science, and presented by our CEO on the main stage of TED2025. Evo was used to create the first AI-generated CRISPR-Cas9, and the first AI whole genome from scratch. Evo 2, featured in Nature, is the largest fully open source AI project across any domain.
In October, we introduced Omnii-1, the world's most advanced multimodal genome language model, and a leap toward general biological intelligence. It unifies 28 biological modalities, spanning DNA, RNA, proteins, epigenomics, and more, in a single model trained on trillions of tokens of biological data In a world first, Omnii-1 designed the first AI-generated bacteriophages to be administered to a human patient with an antibiotic-resistant infection under compassionate use. We released this news alongside seven other project areas, showing the model’s breadth of applications.
The same generative breakthroughs that enable life-saving cures also lowers the barrier to creating engineered threats and AI-generated bioweapons. We believe these forces are inseparable. Radical Numerics was founded to develop both the power to design and the responsibility to defend.
About the Role
As a Member of Technical Staff, Infrastructure & Training Systems at Radical Numerics, you will design and build the systems that make large-scale model training possible across research and deployment workflows. You will work on distributed training, performance optimization, reusable internal frameworks, and the tooling that helps researchers move quickly without sacrificing reliability.
This role is ideal for someone who combines deep systems instincts with an interest in modern machine learning. You should care about how every layer of the stack affects research velocity: kernel performance, communication overhead, fault tolerance, observability, reproducibility, and the ergonomics of the training loop itself.
We believe biological world models will require not only strong research ideas, but exceptional training and inference systems: infrastructure that makes large-scale experimentation efficient, reproducible, and robust enough to support rapid scientific iteration. This role is focused on building that foundation.
What You’ll Do
Design and scale distributed training systems. Build and optimize distributed training infrastructure for large-scale biological world models across large distributed compute systems, with a focus on performance, stability, and scalability.
Maximize throughput and hardware efficiency. Develop performance optimizations across the stack, including communication patterns, memory efficiency, custom kernels, compilation paths, and systems instrumentation, to ensure training compute is used effectively.
Build reusable training frameworks. Develop internal libraries, abstractions, and workflows that improve reproducibility, reliability, and scalability across new model architectures and training recipes.
Improve reliability under rapid iteration. Establish standards and mechanisms for robustness, maintainability, debugging, and safe deployment of fast-moving research infrastructure. That includes fault tolerance, checkpointing, monitoring, experiment hygiene, and incident analysis.
Collaborate across research and engineering. Partner closely with model researchers, training scientists, and data/infrastructure engineers to identify bottlenecks, unblock experiments, and design systems that support new scientific directions rather than constrain them.
Support new architectures and training paradigms. Adapt infrastructure to the needs of multimodal models, long-context training, and evolving model architectures, so the systems stack remains a research multiplier as model requirements change.
What We’re Looking For
Strong engineering track record in distributed systems, high-performance ML infrastructure, training systems, or closely related areas.
Proficiency in building performant, maintainable software in Python, PyTorch, Triton, CUDA, and C++.
Strong understanding of modern deep learning frameworks and their systems internals.
Ability to debug complex, multi-layered systems involving distributed training, memory/performance regressions, and reliability issues in large codebases.
Comfort working in a highly collaborative environment with researchers, engineers, and domain experts, with a bias toward initiative and execution.
Excellent written and verbal communication skills bridging technical and scientific domains.
Nice to Have
Experience with large-scale distributed training for frontier or foundation models.
Contributions to open-source ML systems or infrastructure such as PyTorch, Torchtitan or Megatron-LM.
Familiarity with ML runtimes, compilers, numerics, communication libraries, and custom kernel development.
Experience improving researcher productivity through infrastructure design, developer tooling, or workflow improvements.
Background in applied math, systems, computational biology, or related quantitative sciences.
Why Radical Numerics
Help build the computational foundation for multimodal biological world models aimed at rapid detection, response, and countermeasures across global health.
Work on systems problems at the frontier of distributed training, architecture, and numerics, in service of real biological applications.
Join a collaborative culture that values rigor, creativity, and cross-disciplinary partnership across AI labs, biotechs, hospital systems, and research institutes.
Competitive compensation, comprehensive benefits, and support for continual learning.
Radical Numerics is committed to equal employment opportunity and does not discriminate in any employment opportunities or practices based on an individual's race, color, creed, gender (including gender identity and gender expression), religion (all aspects of religious beliefs, observance or practice, including religious dress or grooming practices), marital status, registered domestic partner status, age, national origin or ancestry (including language use restrictions and possession of a driver’s license issued under California Vehicle Code section 12801.9), natural hair, physical or mental disability, political affiliation, medical condition (including cancer or a record or history of cancer, and genetic characteristics), sex (including pregnancy, childbirth, breastfeeding or related medical condition), genetic information, sexual orientation, military and veteran status or any other consideration made unlawful by federal, state, or local laws. It also prohibits unlawful discrimination based on the perception that anyone has any of those characteristics, or is associated with a person who has or is perceived as having any of those characteristics.
Radical Numerics participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.