Member of Technical Staff, ML Engineer
Radical Numerics · San Francisco
About Us
Radical Numerics is an AI research lab building general biological intelligence. Our mission is to master the code of life, and our purpose is to reduce human suffering.
Our team created Evo, and started the field of generative genomics. Our work was featured on the cover of Science, and presented by our CEO on the main stage of TED2025. Evo was used to create the first AI-generated CRISPR-Cas9, and the first AI whole genome from scratch. Evo 2, featured in Nature, is the largest fully open source AI project across any domain.
In October, we introduced Omnii-1, the world's most advanced multimodal genome language model, and a leap toward general biological intelligence. It unifies 28 biological modalities, spanning DNA, RNA, proteins, epigenomics, and more, in a single model trained on trillions of tokens of biological data In a world first, Omnii-1 designed the first AI-generated bacteriophages to be administered to a human patient with an antibiotic-resistant infection under compassionate use. We released this news alongside seven other project areas, showing the model’s breadth of applications.
The same generative breakthroughs that enable life-saving cures also lowers the barrier to creating engineered threats and AI-generated bioweapons. We believe these forces are inseparable. Radical Numerics was founded to develop both the power to design and the responsibility to defend.
About the role
As a Member of Technical Staff, ML Engineer, this role owns the layer between the models and the people using them: the APIs, batch and compute systems, and services that make inference fast, reliable, and cheap at genome scale. You would build for our scientists and for the partners and developers who build on Omnii, our next-generation genome language model.
You care about throughput, latency, cost, and uptime, and you have real opinions about what a good developer experience feels like. The ML Engineer you build is how Omnii reaches the people using it to advance human health and biosecurity.
This role sits close to our product and data-partnership functions and our modeling team. You translate between what the science needs, what partners can consume, and what the infrastructure can deliver.
What you'll do
Build the inference APIs behind Omnii: real-time serving plus large batch scoring for genome- and variant-scale workloads, where a single job can be millions of sequences, latency-tolerant and cost-sensitive.
Design the compute and orchestration layer: job queues, autoscaling GPU inference, retries, fault tolerance, and the observability to run all of it against real SLAs.
Build the developer-facing product: the API surface, SDKs, and documentation that let an outside team depend on Omnii without hand-holding.
Drive down cost and latency per inference, and make performance predictable enough to price and guarantee.
Package the platform to run inside partner environments that cannot let data leave, including on-prem and air-gapped installs.
Work directly with our scientists and partners to shape the API around real inference workloads.
What we're looking for
You have built and operated backend or distributed systems at production scale, and you owned their reliability.
You have shipped a model as a service that other people depended on. You think in inference, serving, and throughput.
You have built asynchronous or batch job systems at scale. Genome-scale workloads should feel like familiar ground.
You write production code in Python and at least one typed language, and you are comfortable with containers and infrastructure as code.
You have product judgment. You can decide what to expose, what to hide, and how an API should feel to the person calling it.
You operate well with ambiguity and want the ownership of an early technical role.
Nice to have
GPU inference internals: vLLM, TensorRT-LLM, or Triton, with hands-on performance tuning.
Experience deploying software into locked-down environments such as enterprise VPC, on-prem, or air-gapped.
Familiarity with genomics or computational biology, or a real appetite to learn it fast.
Experience standing up an external API product from the first endpoint forward.
Radical Numerics is committed to equal employment opportunity and does not discriminate in any employment opportunities or practices based on an individual's race, color, creed, gender (including gender identity and gender expression), religion (all aspects of religious beliefs, observance or practice, including religious dress or grooming practices), marital status, registered domestic partner status, age, national origin or ancestry (including language use restrictions and possession of a driver’s license issued under California Vehicle Code section 12801.9), natural hair, physical or mental disability, political affiliation, medical condition (including cancer or a record or history of cancer, and genetic characteristics), sex (including pregnancy, childbirth, breastfeeding or related medical condition), genetic information, sexual orientation, military and veteran status or any other consideration made unlawful by federal, state, or local laws. It also prohibits unlawful discrimination based on the perception that anyone has any of those characteristics, or is associated with a person who has or is perceived as having any of those characteristics.
Radical Numerics participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.
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