China Precision Medicine-Pathologist/Pathology Lab Leader
AbbVie · Shanghai
Company Description
About AbbVie
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.
Job Description
Job Description:
As China Precision Medicine-Pathologist/Pathology Lab Leader, you will provide expertise in human disease pathology, experimental pathology support and contribute to the development and interpretation of tissue-based assays across therapeutic areas. You will also be responsible for pathology lab/team setup, project management, data analysis and interpretation of pathology lab testing results.
Key Responsibilities:
Specific responsibilities can include:
- Lead China pathology lab/project development teams or sub-teams. Coordinate with appropriate team members to advance projects efficiently. Focus of the position will be to provide pathology support needed for spatial biology and single cell genomics.
- Contribute to or Lead the design and interpretation of tissue-based studies investigating aspects such as target biology, drug MOA, target pathway activation, pharmacodynamic effects, biomarker prevalence, or drug distribution.
- Contribute to the design, validation and deployment of pathology assays, including the determination of assay parameters such as specificity and sensitivity. Design, implement and oversee pathology-based biomarker and diagnostic testing, including data analysis:
- Develop, validate and implement scoring paradigms for tissue-based assays
- Direct the development, outsourcing and validation of clinically applicable tissue-based assays. Assist in the development of assay protocols as needed.
- Provide pathology input to project teams and ensure access to state-of-the-art tissue-based techniques and samples for target pathway evaluation in human disease:
- Implement technologies and/or methodologies via a combination of in-house efforts and the use of CROs or other external expertise using techniques such as in situ hybridization, immunohistochemistry (including multiplexed), spatial biology image analysis, etc.
- Evaluate the scientific basis and clinical applicability of the proposed assays, their validation status and any related technical issues.
- Assume responsibility for the assessment and scoring of specimens and the preparation of reports summarizing the data, analysis and interpretation of findings.
- Write the relevant pathology-based biomarker and diagnostics testing sections in drug development and registration documents such as clinical study protocols, clinical study reports, investigator brochures, and regulatory submission packages (INDs, NDA’s, BLA's).
- Collaborate with project teams from concept to reagent generation to quantitation and approval plan for CDx as needed.
- Participate in the evaluation of external licensing or collaborative opportunities (including CDx collaborations) and oversee internal components of shared programs.
Qualifications
- Experienced pathologist (MD) or PhD with relevant post-doctoral academic, clinical and/or industry pathology experience -required
- Board certification in pathology (anatomic, clinical, combined, with or without additional specialization) – preferred
- Proven track record with pathology lab/team/project leadership and pathology assay development/validation
- Research experience with spatial biology or multiplex IHC/IF preferred
Additional Information
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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